Fig. 1 |. Comparison of dcw cluster composition and occurrence of SEDS family proteins across diverse Firmicutes species.

The ability to form spores was inferred by the presence of broadly conserved sporulation-specific genes spo0A and spoIIE in the genome (Galperin et al., 2022). SEDS homologs that cluster with the cell elongation-associated RodA encoding genes were excluded from the analyses (Supplementary Fig. 2). For genome accession numbers, coordinates, and taxonomy information, see Supplementary Table 1. The inset tree shows phylogenetic relationships and the presence or absence of sporulation genes (spo0A and spoIIE), dcw-encoded SEDS gene(s), and ftsW orthologs encoded outside the dcw cluster for each organism. The colored circles highlight the presence (black) and loss of sporulation (red) genes, as well as the presence of ftsW/spoVE within (orange) and outside (green) the dcw cluster. For analyses of the full dataset, see Supplementary Fig. 1.