Table 1.
Patient cohort characteristics.
| Development (BCH, n = 214) | External Validation (CBTN, n = 112) | p-values | |
|---|---|---|---|
| Age (years) | 0.19* | ||
| median (range) | 5 (1 – 20) | 6 (1 – 21) | |
| Sex n (%) | 0.82+ | ||
| Female | 95 (44.4%) | 51 (45.5%) | |
| Male | 113 (52.8%) | 55 (49.1%) | |
| Unknown | 6 (2.8%) | 4 (3.6%) | |
| Race/Ethnicity n (%) | 1.076e-06+ | ||
| Non-Hispanic Caucasian/white | 145 (67.8%) | 71 (64.5%) | |
| African American/Black | 6 (2.8%) | 14 (12.7%) | |
| Hispanic/Latinx | 3 (1.4%) | 10 (9.1%) | |
| Asian American/Asian | 9 (4.2%) | 3 (2.7%) | |
| American Indian/Alaska Native | 0 | 1 (0.9%) | |
| More than once race | 0 | 1 (0.9%) | |
| Other/Unknown | 51 (23.8%) | 10 (9.1%) | |
| Histologic diagnosis n (%) | 0.0005+ | ||
| Pilocytic Astrocytoma | 52 (24.2%) | 68 (61.8%) | |
| Fibrillary Astrocytoma | 0 | 8 (7.3%) | |
| Pilomyxoid Astrocytoma | 8 (3.7%) | 17 (15.5%) | |
| Ganglioglioma | 13 (6.1%) | 0 | |
| Dysembryoplastic neuroepithelial tumor | 7 (3.3%) | 0 | |
| Diffuse Astrocytoma | 1 (0.5%) | 7 (6.4%) | |
| Angiocentric Glioma | 1 (0.5%) | 1 (0.9%) | |
| Other Low-Grade Glioma/Astrocytoma |
132 (61.7%) | 9 (8.2%) | |
| BRAF Mutation Status n (%) | 0.0005+ | ||
| V600E | 50 (23.4%) | 17 (15.2%) | |
| Fusion | 60 (28.0%) | 60 (53.6%) | |
| Wildtype | 104 (48.6%) | 35 (31.3%) | |
| Tumor Locations n (%) | 0.0005+ | ||
| Cerebellum/Posterior fossa | 40 (18.7%) | 33 (29.4%) | |
| Temporal lobe | 43 (20.1%) | 12 (10.7%) | |
| Frontal Lobe | 22 (10.3%) | 4 (3.6%) | |
| Suprasellar | 6 (2.8%) | 32 (28.6%) | |
| Optic Pathway | 8 (3.7%) | 17 (14.9%) | |
| Brainstem | 7 (3.3%) | 9 (7.9%) | |
| Thalamus | 15 (7.0%) | 2 (1.8%) | |
| Ventricles | 14 (6.5%) | 2 (11.4%) | |
| Others | 59 (27.6%) | 1 (0.9%) |
CBTN: Children Brain Tumor Network; BCH: Boston Children’s Hospital. The Kruskal-Wallis rank sum test (*) was performed for numerical data age to test the statistical significance between age medians. The Fisher’s Exact test (+) was performed for categorical data to test the statistical significance differences between CBTN and BCH datasets. A p-value less than 0.05 is statistically significant.