Table 2.

The pipeline’s performance on classification on BRAF status for internal validation set and external validation set.

	BRAF Status	AUC (95%CI)	Sensitivity	Specificity	Accuracy	Precision	Recall	F1-Score
Internal Validation (n=59)	Wild-type	0.82 (0.75 – 0.91)	0.73	0.80	0.77	0.76	0.77	0.77
	BRAF Fusion	0.87 (0.61 – 0.97)	0.87	0.70	0.81	0.81	0.80	0.80
	BRAF V600E	0.85 (0.66 – 0.95)	0.75	0.80	0.76	0.82	0.77	0.77
	Composite	0.84 (70 – 90)	0.77	0.76	0.77	0.78	0.77	0.77
External Validation (n=112)	Wild-type	0.72 (0.64 – 0.86)	0.72	0.71	0.72	0.75	0.72	0.73
	BRAF Fusion	0.78 (0.61 – 0.89)	0.60	0.90	0.75	0.77	0.74	0.74
	BRAF V600E	0.72 (0.64 – 0.88)	0.78	0.60	0.75	0.82	0.74	0.77
	Composite	0.73 (0.68 –0.88)	0.66	0.79	0.75	0.77	0.73	0.74