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. 2023 Mar 4;17(8):1193–1206. doi: 10.1093/ecco-jcc/jjad038

Table 5.

Clinical factors associated with the presence of perianal lesions at the diagnosis of CD

Parameter Univariate analysis Multivariate analysis
N Patients with perianal lesion, n [%] OR [95% CI] p-Value N Patients with perianal lesion, n [%] OR [95% CI] p-Value
Sex Female 210 91 [43.3] 167 73 [43.7]
Male 452 233 [51.5] 1.391 [1.001; 1.934] p = 0.049* 343 182 [53.1] 1.566 [1.029; 2.384] p = 0.037*
Age, years ≥40 127 26 [20.5] 96 18 [18.8]
<40 535 298 [55.7] 4.884 [3.072; 7.765] p < 0.001* 414 237 [57.2] 4.181 [2.288; 7.639] p < 0.001*
BMI, kg/m2 <20.53 300 157 [52.3] 296 154 [52.0]
≥20.53 217 102 [47.0] 0.808 [0.569; 1.146] p = 0.232 214 101 [47.2] 0.960 [0.652; 1.414] p = 0.837
Family history No 626 306 [48.9] 485 242 [49.9]
Yes 34 18 [52.9] 1.176 [0.589; 2.349] p = 0.645 25 13 [52.0] 0.859 [0.356; 2.075] p = 0.736
Disease location L1 150 51 [34.0] 117 38 [32.5]
L2 108 45 [41.7] 1.386 [0.832; 2.310] p = 0.210 77 33 [42.9] 1.450 [0.746; 2.818] p = 0.273
L3 396 224 [56.6] 2.528 [1.708; 3.741] p < 0.001* 316 184 [58.2] 2.259 [1.379; 3.700] p = 0.001*
Disease behaviour B1 416 221 [53.1] 310 171 [55.2]
B2 171 62 [36.3] 0.502 [0.348; 0.724] p < 0.001* 140 53 [37.5] 0.544 [0.345; 0.856] p = 0.009*
B3 71 37 [52.1] 0.960 [0.580; 1.589] p = 0.874 60 31 [51.7] 1.258 [0.675; 2.344] p = 0.470
EIM No 639 311 [48.7] 490 244 [49.8]
Yes 23 13 [56.5] 1.371 [0.593; 3.172] p = 0.461 20 11 [55.0] 1.282 [0.480; 3.422] p = 0.620
Smoking history#1 No 447 237 [53.0] 345 188 [54.5]
Yes 213 87 [40.8] 0.612 [0.440; 0.851] p = 0.004* 165 67 [40.6] 0.951 [0.600; 1.507] p = 0.832
Alcohol intake#2 No 479 250 [52.2] 372 199 [53.5]
Yes 180 74 [41.1] 0.639 [0.452; 0.905] p = 0.012* 138 56 [40.6] 0.589 [0.376; 0.922] p = 0.020*

Abbreviations: BMI, body mass index; CI, confidence interval; EIM, extra-intestinal manifestation; OR, odds ratio.

#1Smoking history: ‘Yes’ is the total of ‘I am smoking now’ and ‘I have smoked in the past’.

#2Alcohol intake: ‘Yes’ is the total of ‘sometimes drink’ and ‘drink often’, and ‘no’ is the total of ‘do not drink/stop’ and ‘almost never drink’.

Logistic regression analysis with sex, age, BMI, family history, disease location, disease behaviour, extra-intestinal manifestation [EIM], smoking history and alcohol intake as covariates.

*p < 0.05.