Figure 3.

Patients within the conventional [CONV] treatment group treated with exclusive enteral nutrition [EEN] or oral prednisolone show similar immune signatures at 10–14 weeks. [A] Fold changes in the median protein concentrations of all 83 proteins between baseline and 10–14 weeks for patients who received EEN or prednisolone treatment; Wilcoxon signed-rank test. [B] Volcano plot of median protein concentrations at 10–14 weeks for EEN-treated patients [n = 18] compared to oral prednisolone-treated patients [n = 14]. None of the 83 proteins with |log₂FC| < 0.5 were significantly different after FDR correction; Mann–Whitney U-test. [C] The concentration of interleukin [IL]-7 was higher in prednisolone patients while the concentration of adenosine deaminase [ADA] was lower in prednisolone- compared to EEN-treated patients at weeks 10–14; binary logistic regression analysis. [D] After FDR correction, the concentrations of IL-7 and ADA did not reduce significantly between baseline and after 10–14 weeks of induction treatment in either EEN- or prednisolone-treated patients; Wilcoxon signed-rank test; p < 0.05 was considered significant for all tests.