Fig. 6.
A. Comparison between equilibrium uptake of hydrophilic CPC +N and its hydrophobic counterpart CPC +F in healthy and 90% GAG depleted cartilage in PBS.B.% Intra-cartilage CPC retention following 24 h desorption in 1x and 10x PBS bath Adapted with permission from [1]. Dissociation constants (Kd) and cooperativity factors (n) are determined using MST for binding between chondroitin sulfate (CS) and C. CPC +N or D. CPC +F. E. Intra-cartilage uptake of CPC +N and CPC +F equilibrated in γ-Globulin at physiological SF concentration F. Intra-cartilage uptake of CPC +N and CPC +F equilibrated in healthy and OA SF. * vs healthy, # vs corresponding condition in CPC +N; p < 0.05.