TABLE 2.

Pharmacological effects of the novel DM compounds on apparent affinity to GABA in the α1β3γ2L GABA_AR

Compound	Kd,GABA (number of cells), μM	Kd,GABA (DM) (number of cells), μM	Kd,GABA/Kd,GABA (DM) (fold difference)
DM497	16.8 ± 1.6 (22)	0.2 ± 0.2 (16)	84
DM490	16.5 ± 1.2 (15)	0.2 ± 0.02 (14)	75
DM492	16.5 ± 1.2 (15)	0.3 ± 0.03 (18)	63
DM489	19.0 ± 1.1 (16)	2.1 ± 0.2 (12)	9.1
DM495	13.0 ± 1.1 (20)	1.5 ± 0.1 (15)	8.4
DM480	13.0 ± 1.1 (20)	4.6 ± 0.4 (16)	2.9

K_d,GABA and K_{d,GABA (DM)} reflect the apparent binding affinities to GABA in the absence or presence of 100 µM of each tested DM compound. The table gives means ± propagated errors (numbers of cells) for K_d,GABA and K_{d,GABA (DM)} calculated using eq. (2).