Table 3.
ROC Curve Data
| Cut-Off | Sensitivity | Specificity | AUC | P-value | 95% CI | Z-P-valuea | |
|---|---|---|---|---|---|---|---|
| Single indicator | |||||||
| NLR | 4.43 | 0.891 | 0.659 | 0.847 | <0.001 | 0.810–0.884 | NE |
| LMR | 0.38 | 0.813 | 0.609 | 0.773 | <0.001 | 0.719–0.826 | 0.003 |
| ENR | 0.01 | 0.734 | 0.709 | 0.745 | <0.001 | 0.697–0.794 | <0.001 |
| PLR | 176.49 | 0.766 | 0.635 | 0.709 | <0.001 | 0.643–0.775 | <0.001 |
| ELR | 0.04 | 0.625 | 0.661 | 0.616 | 0.010 | 0.540–0.692 | <0.001 |
| PMR | 15.96 | 0.508 | 0.722 | 0.604 | 0.050 | 0.524–0.684 | <0.001 |
| RDW | 14.05 | 0.69 | 0.760 | 0.753 | <0.001 | 0.691–0.815 | 0.012 |
| CRP (N=3668) | 1.065 | 0.867 | 0.578 | 0.763 | <0.001 | 0.699–0.826 | 0.064 |
| ESR (mm/L) (N=3966) | 12.5 | 0.771 | 0.563 | 0.673 | <0.001 | 0.590–0.756 | 0.002 |
| Combined indicators | |||||||
| NLR+LMR | 15.963 | 0.938 | 0.623 | 0.849 | <0.001 | 0.810–0.888 | 0.808 |
| NLR+ENR | 0.018 | 0.766 | 0.740 | 0.818 | <0.001 | 0.768–0.869 | 0.063 |
| NLR+PLR | 0.011 | 0.875 | 0.673 | 0.839 | <0.001 | 0.791–0.886 | 0.548 |
| NLR+ELR | 0.012 | 0.859 | 0.688 | 0.836 | <0.001 | 0.824–0.847 | 0.280 |
| Multiple indicators | |||||||
| NLR+PLR+LMR | 0.011 | 0.891 | 0.698 | 0.860 | <0.001 | 0.821–0.898 | 0.167 |
| NLR+LMR+ENR | 0.020 | 0.719 | 0.809 | 0.829 | <0.001 | 0.780–0.878 | 0.249 |
| NLR+ELR+LMR | 0.011 | 0.922 | 0.634 | 0.845 | <0.001 | 0.834–0.856 | 0.887 |
| NLR+ENR+PLR | 0.019 | 0.734 | 0.775 | 0.822 | <0.001 | 0.771–0.874 | 0.157 |
| NLR+ENR+ELR | 0.019 | 0.766 | 0.731 | 0.825 | <0.001 | 0.813–0.836 | 0.105 |
| NLR+ELR+PLR | 0.012 | 0.813 | 0.734 | 0.833 | <0.001 | 0.821–0.844 | 0.361 |
| NLR+LMR+ENR+PLR | 0.018 | 0.781 | 0.771 | 0.835 | <0.001 | 0.786–0.885 | 0.477 |
| NLR+LMR+PLR+ELR | 0.011 | 0.922 | 0.678 | 0.857 | <0.001 | 0.846–0.867 | 0.407 |
| NLR+LMR+ENR+ELR | 0.021 | 0.719 | 0.805 | 0.834 | <0.001 | 0.822–0.845 | 0.346 |
| NLR+ENR+PLR+ELR | 0.017 | 0.812 | 0.717 | 0.827 | <0.001 | 0.815–0.838 | 0.257 |
| NLR+LMR+ENR+PLR+ELR | 0.017 | 0.797 | 0.727 | 0.837 | <0.001 | 0.826–0.848 | 0.548 |
Notes: aZ-P value was calculated by MedCalc software. The value of Z-P means the difference between NLR and other inflammatory biomarkers.
Abbreviations: NLR, neutrophil to lymphocyte ratio; LMR, lymphocyte to monocyte ratio; ENR, eosinophil to neutrophil ratio; PLR, platelet to lymphocyte ratio; RDW, red cell volume distribution width; ELR, eosinophil to lymphocyte ratio; PMR, platelet to mean platelet volume ratio; CRP, C-reactive protein; ESR, erythrocyte sedimentation rate; AUC, area under concentration time curve; CI, confidence interval; NE, No evaluation.