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(A) The neurovascular unit. The neurovascular unit consists of endothelial cells surrounded by a basement membrane, astrocytes, pericytes, and neurons. This four-cell structure also known as the “neurovascular unit” is responsible for the regulation of blood-brain barrier function. (B) History of the blood-brain barrier. Timeline of fundamental discoveries made in the blood-brain barrier field. Created with BioRender.com.
