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(A) History of ABCB1. From the discovery of the “permeability glycoprotein” by Juliano and Ling in 1976 to structural insights into substrate and inhibitor discrimination by human ABCB1 revealed by Alam and Locher in 2019. (B) ABCB1 structure. ABCB1 consists of two transmembrane domains TMD1 and TMD2, each of which has six transmembrane spanning α-helices and a nucleotide binding domain (NBD1 and NBD2). ABCB1 is N-glycosylated at the first extracellular loop. Created with BioRender.com.
