Table 2.
Cryptic RNA accumulation associates with higher pTDP-43 protein levels in AD-TDP.
| Unadjusted analysis | Adjusting for age at death, sex, RIN and TDP-43 type | |||
|---|---|---|---|---|
| Group | Regression coefficient (95% CI) | P-value | Regression coefficient (95% CI) | P-value |
| Amygdala | ||||
| STMN2 | 0.007673 (0.002224 to 0.013120) | 0.0065 | 0.009574 (0.003768 to 0.015380) | 0.0016 |
| KCNQ2 | 0.003975 (0.000553 to 0.007396) | 0.0235 | 0.004944 (0.001248 to 0.008639) | 0.0096 |
| UNC13A | 0.000310 (-0.000149 to 0.000769) | 0.1819 | 0.000422 (-0.000203 to 0.001048) | 0.0800 |
| CAMK2B | 0.000438 (8.75e-5 to 0.000789) | 0.0151 | 0.000538 (0.000158 to 0.000918) | 0.0620 |
| SYT7 | 0.000137 (-0.000371 to 0.000645) | 0.5368 | 0.000219 (-0.000337 to 0.000775) | 0.4333 |
| Hippocampus | ||||
| STMN2 | 0.002044 (-0.000590 to 0.004679) | 0.1262 | 0.002504 (-0.000482 to 0.005490) | 0.0988 |
| KCNQ2 | 0.008518 (0.003578 to 0.013460) | 0.0010 | 0.007834 (0.002402 to 0.013270) | 0.0054 |
| UNC13A | 0.000259 (6.86e-5 to 0.000449) | 0.0084 | 0.000313 (9.98e-5 to 0.000526) | 0.0046 |
| CAMK2B | 3.50e-5 (-0.000383 to 0.000452) | 0.8693 | 1.23e-5 (-0.000455 to 0.000480) | 0.9583 |
| SYT7 | 1.46e-11 (7.13e-12 to 2.12e-11) | 0.0002 | 1.51e-11 (6.57e-12 to 2.37e-11) | 0.0008 |
CI = confidence interval, RIN: RNA integrity number; regression coefficients, 95% CIs, and P values are shown for associations of pTDP-43 from unadjusted linear regression models or linear regression models adjusted for age, sex, RIN and TDP-43 subtype. P values < 0.01 are considered statistically significant.