Table 3.
Demographic data and parameters of different groups.
| Characteristics | Group 1 | Group 2 | Group 3 | p-Value |
|---|---|---|---|---|
| Cycles, n | 17 | 31 | 933 | |
| Age at retrieval, years (mean ± SD) | 30.9 ± 6.4 | 35.3 ± 3.6 | 34.8 ± 4.2 | <0.0001 a,b |
| Body mass index, kg/m2 (mean ± SD) | 22.7 ± 3.0 | 26.1 | 21.9 ± 3.4 | <0.0001b,c |
| AMH, ng/ml (mean ± SD) | 6.1 ± 3.7 | 5.2 ± 3.7 | 6.2 ± 4.2 | NS |
| COS protocols | NS | |||
| Antagonist | 16 | 21 | 734 | |
| PPOS | 1 | 10 | 199 | |
| Serum hormone level at start of ovarian stimulation (mean ± SD) | ||||
| FSH, IU/L (mean ± SD) | 5.0 ± 2.93 | 6.3 ± 6.9 | 6.73 ± 2.6 | 0.0369 a |
| LH, IU/L (mean ± SD) | 1.4 ± 0.3 | 1.9 ± 0.3 | 5.5 ± 2.7 | <0.0001a,b,c |
| E2, pg/ml (mean ± SD) | 49.4 ± 59.4 | 45.1 ± 27.6 | 40.6 ± 22.8 | NS |
| Progesterone, ng/ml (mean ± SD) | 0.5 ± 0.28 | 0.5 ± 0.2 | 0.4 ± 0.3 | NS |
| LH max, IU/L (mean ± SD) | 1.6 ± 0.4 | 5.4 ± 3.5 | 7.0 ± 4.7 | <0.0001a,b |
| Fertilizing method | NS | |||
| All IVF, n | 2 | 1 | 34 | |
| 1/2 ICSI, n | 5 | 10 | 161 | |
| All ICSI, n | 9 | 13 | 535 | |
| Outcome | ||||
| Retrieved oocytes/cycle (mean ± SD) | 24.0 ± 8.7 | 23.3 ± 10.9 | 23.7 ± 9.9 | NS |
| Oocyte yield rate (mean ± SD) | 78.2 ± 22.8 | 89.4 ± 15.1 | 89.6 ± 13.4 | 0.0031a,b |
| Suboptimal response cycle, n (%) | 4/17 (23.5%) | 2/31 (6.45%) | 34/933 (3.64%) | 0.0002 |
| Maturity rate (mean ± SD) | 84.4 ± 10.1 | 86.1 ± 14.5 | 83.7 ± 13.4 | NS |
| Fertilize rate (mean ± SD) | 71.4 ± 13.8 | 63.2 ± 23.7 | 64.7 ± 17.7 | NS |
| Clinical pregnancy rate, n (%) | 11/16 (68.7%) | 14/24 (58.3%) | 334/730 (45.7%) | NS |
| Ongoing pregnancy rate, n (%) | 10/16 (62.5%) | 14/24 (58.3%) | 329/730 (45.1%) | NS |
| Live birth rate, n (%) | 9/16 (56.3%) | 11/24 (45.8%) | 296/730 (40.55%) | NS |
| Complication | ||||
| OHSS rate, n (%) | 0/17 (0%) | 0/31 (0%) | 3/933 (0.32%) | NS |
AMH, anti-Mullerian hormone; COS, controlled ovarian stimulation; PPOS, progestin-primed ovarian stimulation; FSH, follicle-stimulating hormone; LH, luteinizing hormone; IVF, in vitro fertilization; ICSI, intracytoplasmic sperm injection; OHSS, ovarian hyperstimulation syndrome.
a
Significant between Groups 1 and 3.
b
Significant between Groups 1 and 2.
c
Significant between Groups 2 and 3.
Bold means the p value <0.05, which is significant.