Fig 4. Evaluation of the optimization algorithm using clinical microbiome reference values.

A: Evolution of biomass fraction distribution for the cycles of adaptation enforced by the gradient descendant algorithm using a value of α = 0.125 and a microbiome composition from Mexican patients published by [20]; B: Comparison of pie charts for the clinical reference biomass percentage distributions (left) and the obtained with the modeling strategy based on the gradient descent algorithm (right); C: Performance functional (J) evolution using clinical data from healthy Mexican patients for the simulation.