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. 2023 Aug 9;17(8):e0011542. doi: 10.1371/journal.pntd.0011542

Fig 2. Differential seroprevalence of TSSA variants across the Americas.

Fig 2

A) Arrays made up of consecutive 16mer peptides and spanning the complete sequences of TSSA reference variants were probed with serum samples from chronic Chagas disease patients of different geographic origin, and the reactivity of each TSSA (indicated with a color scale) was calculated as the sum of the reactivities of its constituent peptides. B) TSSA reactivity features of the population analyzed as a whole (top), or upon stratification in Southern cone countries’ samples (middle) and Northern South America and North American samples (bottom). In every case, the overall TSSA seroprevalence is indicated by pie charts to the left. The bar charts show the primary reactivity (the most reactive TSSA isoform, left chart), and the number of isoforms recognized by TSSA-reactive sera (right chart). The y-axis refers to the number of samples.