Figure 12.

Effect of GADD45B on signal communication in gastric cancer microenvironment. (A) Microenvironmental signal changes in chronic atrophic gastritis pathogenesis. (B) Changes in microenvironment signals during the pathogenesis of gastric cancer. (C) Signaling pathways in which epithelial cells undergo significant changes during the pathogenesis of GC. (C, D) The importance of GADD45B-high gastric cancer cells and GADD45B-low gastric cancer cells in the communication network in the GC microenvironment. (E–H) The main participants of the CD99 signaling pathway network in the GC microenvironment and the importance of the participants. (I) CD99-CD99 is the most important ligand-receptor in the CD99 signaling pathway network. (J–M) The main participants of the CDH signaling pathway network in the GC microenvironment and the importance of the participants. (N) CDH1-CDH1 was the most important ligand-receptor in the CDH signaling pathway network.