TABLE 1.

Quantification of neuronal MV infection and lymphocyte infiltration in neonate and adult mice^a

Days p.i.	Site	Neonates (5 to 6 days)			Adults (45 to 60 days)
		MV	CD4+	CD8+	MV	CD4+	CD8+
3	Parenchyma	++	+	−	−	++	+
	Meninges and ventricles	−	++	−	−	++	+
6	Parenchyma	+++	++	+	−	+++	+++
	Meninges and ventricles	−	++	+	−	+++	+++

^aAt least four mice each of neonatal and adult line 18 NSE-CD46⁺ mice were inoculated i.c. with 3 × 10⁴ PFU MV-Edmonston. After 3 or 6 days postinfection, mice were sacrificed and brains were collected for cryostat sectioning. Frozen brain sections from each mouse were stained as described in Fig. 3 and in Materials and Methods. Positively labeled cells were counted over the entire section, and assigned to a range as follows: −, 0 to 10 cells; +, 11 to 50 cells; ++, 51 to 250 cells; +++, >250 cells. The data shown are average results from multiple levels of at least two brains per group. Similar results were obtained with line 52 transgenic mice.