Table 5.

Nanoemulsion based hydrogels preparations for wound healing.

Sl. No.	Drug	Method	Additives	Droplet size	Zeta potential	Model used	Salien t features	References
1.	Thymoquinone	High energy emulsification technique.	Oleic acid, isopropyl myristate, isopropyl alcohol, ethyl oleate, castor oil, sesame oil, PEG 400, tween 20, tween 80.	40.02±0.83 to 99.66±1.43 nm	−26.7 to −30.6 mV	Wistar rats	Hastens wound healing process.	107
2.	Growth Factor (epidermal growth factor (EGF), insulin-like growth factor-I (IGF-I).	Oil-phase titration	Oleic acid, Labrasol, Transcutol.	127±4.30 nm	−24.29 mV	NH 3T mouse cells	Rapid and prolonged wound healing.	108
3.	Beta-glucan	Ultrasonication	Alginate, chitosan, soybean oil, span 80, tween 80.	200 nm	−38.8 mV	Human dermal fibroblast cells.	Bacterial growth inhibitory activity.	67
4.	Atorvastatin	Homogenization	Carboxymethyl cellulose, tween 80 and propylene glycol.	148 nm	–	Wistar rat	Improved wound healing activity.	109
5.	β-caryophyllene	High-speed homogenization	Span 20, tween 20, paraplast.	284.82±1.438 nm	−35.72±1.103 mV	Rat paw edema and mouse ear edema.	Superior bioadhesiveness.	66
6.	Curcumin	Ultrasonication	Carbopol 940, tween 20, tween 40.	56.25±0.69 nm	−20.26±0.65 mV	Rats	Exhibited thixotropic rheological behavior.	110
7.	Tea tree oil	Spontaneous emulsification.	Poly(caprolactone), span 80, tween 80.	198 nm	−11.5 mV	Wistar rats	Increase the biological activities of oil and protect the skin damage.	68