Table 6.

Univariate and multivariate analysis for OS using cox regression in RCC.

		Univariate analysis		Multivariate analysis
Characteristics	Total (N)	Hazard ratio (95% CI)	P	Hazard ratio (95% CI)	P
Age	121	1.019 (0.996–1.043)	0.105
Sex	121		0.299
Male	91	Reference
Female	30	0.687 (0.330–1.430)	0.316
Tumor size	121		0.328
≤5 cm	68	Reference
>5 cm	53	1.345 (0.744–2.431)	0.327
AJCC stage	121		<0.001***
Stage1	27	Reference		Reference
Stage2	45	6.512 (1.510–28.082)	0.012*	5.688 (1.197–27.037)	0.029*
Stage3	49	9.122 (2.154–38.637)	0.003**	5.609 (1.227–25.649)	0.026*
Differentiation	121		0.018*
Well	12	Reference		Reference
Moderate	85	5.253 (0.716–38.535)	0.103	1.782 (0.229–13.852)	0.581
Poor	24	8.769 (1.146–67.082)	0.036*	2.534 (0.293–21.947)	0.399
Tumor budding	121		0.011*
Negative	15	Reference		Reference
Weak	73	3.740 (0.892–15.682)	0.071	2.592 (0.605–11.107)	0.199
Moderate	28	2.862 (0.618–13.250)	0.179	1.320 (0.263–6.625)	0.736
Strong	5	15.819 (2.871–87.172)	0.002**	4.199 (0.700–25.188)	0.116
Venous invasion	121		<0.001***
Negative	92	Reference		Reference
Positive	29	3.143 (1.719–5.746)	<0.001***	2.246 (1.144–4.407)	0.019*
Perineural invasion	121		0.004**
Negative	75	Reference		Reference
Positive	46	2.372 (1.309–4.297)	0.004**	1.095 (0.543–2.208)	0.801
MMR status	121		0.694
dMMR	25	Reference
pMMR	96	1.164 (0.541–2.503)	0.698
TLS density	121	0.879 (0.824–0.939)	<0.001***	0.915 (0.852–0.982)	0.014*

*P<0.05.

**P<0.01.

***P<0.001.