Table 2.
Clinical and anthropometrics characteristics in study subjects according to IGF1 (rs35767) genotypes
GG (n = 191) | AG (n = 72) | AA (n = 15) | p value | |
---|---|---|---|---|
Age | 14.40 ± 3.02 | 14.64 ± 3.06 | 15.50 ± 1.96 | 0.362 |
Males, n (%) | 102 (53.4) | 34 (47.2) | 10 (66.7) | 0.355 |
Years of diabetes | 7.41 ± 3.67 | 7.60 ± 3.48 | 9.10 ± 2.73 | 0.210 |
Body height (cm) | 160.4 ± 13.8 | 161.7 ± 14.1 | 167.6 ± 11.2 | 0.140 |
Body weight (kg) | 55.82 ± 15.89 | 57.17 ± 15.89 | 61.00 ± 11.90 | 0.425 |
BMI | 21.22 ± 3.65 | 21.40 ± 3.42 | 21.57 ± 3.09 | 0.888 |
BMI z-score | 0.39 ± 0.87 | 0.47 ± 0.97 | 0.30 ± 0.83 | 0.947 |
SBP (mmHg) | 107.6 ± 11.0 | 107.7 ± 10.4 | 106.8 ± 9.0 | 0.960 |
SBP percentile | 36.4 [17.8–61.2] | 32.8 [18.8–56.5] | 33.0 [2.8–56.4] | 0.608 |
DBP (mmHg) | 68.0 ± 7.9 | 68.5 ± 5.7 | 70.5 ± 7.3 | 0.416 |
DBP percentile | 61.8 [44.4–77.8] | 58.6 [45.0–75.4] | 68.0 [45.6–78.8] | 0.728 |
HbA1c (%) | 8.0 [7.4–8.5] | 7.9 [7.3–8.5] | 8.1 [7.5–8.4] | 0.702 |
Serum creatinine (mg/dL) | 0.63 ± 0.15 | 0.65 ± 0.15 | 0.73 ± 0.10 | 0.033 |
eGFR (mL/min) | 109.8 ± 20.8 | 106.3 ± 18.9 | 96.7 ± 12.9 | 0.033 |
ACR (mg/mmol) | 0.35 [0.20–0.67] | 0.38 [0.20–0.80] | 0.59 [0.24–1.22] | 0.332 |
Data are expressed as means ± SD, medians [IQR]. Differences among groups were tested by ANOVA for normally distributed continuous variables, and the Kruskal–Wallis’s test for skewed variables
In bold statistically significant differencies are reported
BMI body mass index, SBP systolic blood pressure, DBP diastolic blood pressure, ACR albumin-to-creatinine ratio