Table 5.

Multivariate linear regression analysis in the total sample for markers of renal function (eGFR and ACR) using clinical and glycemic parameters and the additive genetic interaction (PPARG + IGF1) as independent variables

Dependent variable	Independent variables	β-coefficient [95% CIs]	p-value
eGFR (mL/min)	Age	−3.18 [−3.94 to −2.43]	< 0.001
	Sex	7.39 [3.23 to 11.6]	0.001
	T1D duration	−0.30 [−0.93 to 0.33]	0.348
	BMI z-score	−1.24 [−3.56 to 1.06]	0.290
	SBP percentile	−0.03 [−0.11 to 0.06]	0.521
	DBP percentile	0.06 [−0.05 to 0.17]	0.301
	HbA1c	19.43 [1.49 to 37.38]	0.034
	PPARG + IGF1	−3.59 [−6.52 to −0.66]	0.017
ACR (mg/mmol)	Age	−0.01 [−0.11 to 0.09]	0.803
	Sex	0.59 [0.48 to 1.14]	0.033
	T1D Duration	−0.02 [−0.10 to 0.07]	0.717
	BMI z-score	−0.16 [−0.47 to 0.15]	0.315
	SBP percentile	0.00 [−0.01 to 0.01]	0.978
	DBP percentile	0.00 [−0.01 to 0.02]	0.868
	HbA1c	0.61 [−1.76 to 2.98]	0.614
	PPARG + IGF1	0.01 [−0.38 to 0.40]	0.952

R² = 0.310, p < 0.001

R² = 0.028, p = 0.641

Statistical test performed on log-transformed HbA1c values

Bold values represent statistically significant results

SBP systolic blood pressure, DBP diastolic blood pressure