Table 14.
Metformin effects on maternal/fetal outcomes and offspring metabolic profile
| Maternal outcomes | Fetal outcomes | Offspring | ||||||
|---|---|---|---|---|---|---|---|---|
| Condition | Fertility | GWG | GDM rate | Insulin need | Preterm delivery | Miscarriage | Birth weight | Metabolic Profile |
| Overweight | No available data | = | = | NA | / | / | = | = |
| Obesity | No available data | Reduced | = | NA | / | Reduced | = | = |
| PCOS | Improved | Reduced | = | / | Reduced | = | = | Impaired |
| ART (in PCOS women) | Improved | No available data | No available data | NA | No available data | / | / | No available data |
| GDM | No available data | Reduced | NA | Reduced | = | = | Lower | Impaired |
| T2DM | No available data | Reduced | NA | Reduced | = | = | Lower | = |
GWG, Gestational weight gain. NA, Not applicable. Cells with “/“ indicate inconsistent data
Cells with “ = ” indicate similar results to comparator