Table 2.

Electrophysiology and PIN data.

	Controls (n = 23)	T1D (n = 9)	T2D (n = 24)	KW testa (p-value)	Controls vs. T1Db (p-value)	Controls vs. T2Db (p-value)	T1D vs. T2Db (p-value)
Electrophysiology
sSCV (m/s)	45 [42.8–50]c	40 [34.5–47.5]	43 [40–44]e	0.007	0.029	0.004	0.435
sSAMP (μV)	8 [5–13]c	6 [2–14]d	3 [2–6]	0.001	0.358	< 0.001	0.209
pMCV (m/s)	46 [43–49]c	39 [34–43]	40 [37–45]	< 0.001	0.001	< 0.001	0.373
uSCV (m/s)	54 [48–56]c	52 [43–54]	48 [45–53]e	0.039	0.156	0.013	0.570
uSAMP (μV)	6 [3–8]c	3 [2–8]	4 [3–4]e	0.035	0.135	0.011	0.814
uMCV (m/s)	58 [54–62]c	52 [49–56]	56 [50–57]e	0.011	0.010	0.023	0.247
uAMP wrist (μV)	7 [6–9]c	8 [5.6–8.7]	6 [5–7]e	0.043	0.948	0.015	0.136
Morphometrics
PIN MNFD (No./mm2)	5,893 [4,959–7,617]	4,575 [3,942–6,057]	5,356 [4,751–6,538]	0.093	N/A	N/A	N/A
Proteomics
No. of proteins	2,540 [2,516–2,564]	2,536 [2,484–2,562]	2,532 [2,467–2,553]	0.645	N/A	N/A	N/A

Lower extremity parameters are sural nerve sensory conduction velocity (sSCV), sural nerve amplitude (sAMP), and peroneal nerve motor conduction velocity (pMCV). Parameters from the upper extremity are obtained from the ulnar nerve and include sensory amplitude (uSAMP), sensory conduction velocity (uSCV), motor conduction velocity (uMCV), and motor amplitude at the wrist level (uAMP wrist). Electrophysiology data are presented as median [quartiles] for each study group. The Kruskal–Wallis test with post hoc Mann–Whitney U-test was used to compare the groups. A p-value of < 0.05 was considered to be statistically significant. Electrophysiology and morphometrics data have been previously published by Eriksson et al. (1994); Thomsen et al. (2009a,b), and Ekman et al. (2020).

N/A, not applicable.

^aKW, Kruskal–Wallis test.

^bMann–Whitney U-test.

^cn = 22.

^dn = 8.

^en = 23.