Table 3.
Identified heat shock proteins by group.
| HSP 70 superfamily: HSPA (HSP 70) and HSPH (HSP110) families | |||
|---|---|---|---|
| Subgroup | Name | Gene | Uniprot |
| HSPA | Heat shock 70 kDa protein 1A (HSP70-1/HSP72) | HSPA1A | P0DMV8 |
| Heat shock 70 kDa protein 1-like | HSPA1L | P34931 | |
| Heat shock-related 70 kDa protein 2 | HSPA2 | P54652 | |
| Heat shock 70 kDa protein 4 | HSPA4 | P34932 | |
| Heat shock 70 kDa protein 4L | HSPA4L | O95757 | |
| Endoplasmic reticulum chaperone BiP | HSPA5 | P11021 | |
| Heat shock 70 kDa prote in 6 | HSPA6 | P17066 | |
| Putative heat shock 70 kDa protein 7 | HSPA7 | P48741 | |
| Heat shock cognate 71 kDa protein | HSPA8 | P11142 | |
| Stress-70 protein, mitochondrial | HSPA9 | P38646 | |
| Heat shock 70 kDa protein 12A | HSPA12A | O43301 | |
| Heat shock 70 kDa protein 12B | HSPA12B | Q96MM6 | |
| HSPH | Heat shock protein 105 kDa | HSPH1 | Q92598 |
| The DNAJ family (HSP40) | |||
| DnaJA | DnaJ homolog subfamily A member 2 | DNAJA2 | O60884 |
| DnaJB | DnaJ homolog subfamily B member 2 | DNAJB2 | P25686 |
| DnaJ homolog subfamily B member 4 | DNAJB4 | Q9UDY4 | |
| DnaJC | DnaJ homolog subfamily C member 11 | DNAJC11 | Q9NVH1 |
| The HSPB family (small heat shock proteins) | |||
| HSPB | Heat shock protein beta-1 (HSP27) | HSPB1 | P04792 |
| Heat shock protein beta-6 | HSPB6 | O14558 | |
| Heat shock protein beta-8 | HSPB8 | Q9UJY1 | |
| The HSP90/HSPC family | |||
| HSPC | Heat shock protein HSP 90-alpha | HSPC1/HSP90AA1 | P07900 |
| Heat shock protein HSP 90-alpha A2 | HSP90AA2P | Q14568 | |
| Putative heat shock protein HSP 90-alpha A5 | HSP90AA5P | Q58FG0 | |
| Heat shock protein HSP 90-beta | HSPC3/HSP90AB1 | P08238 | |
| Putative heat shock protein HSP 90-beta 2 | HSP90AB2P | Q58FF8 | |
| Putative heat shock protein HSP 90-beta-3 | HSP90AB3P | Q58FF7 | |
| Putative heat shock protein HSP 90-beta 4 | HSP90AB4P | Q58FF6 | |
| Endoplasmin | HSPC4/HSP90B1 | P14625 | |
| Putative endoplasmin-like protein | HSP90B2P | Q58FF3 | |
| Heat shock protein 75 kDa, mitochondrial (TRAP1) | HSPC5/TRAP1 | Q12931 | |
| Chaperonins and related genes | |||
| HSPD | 60 kDa heat shock protein, mitochondrial | HSPD1 | P10809 |
| HSPE | 10 kDa heat shock protein, mitochondrial | HSPE1 | P61604 |
In total, 32 different heat shock proteins were identified among subjects with T1D, T2D, and controls. HSP90-alpha A5 was missing in one subject with T2D and HSP beta-8 was missing in six subjects with diabetes (T1D: n = 2; T2D: n = 4) but present in all other subjects.