TABLE 1.
Phenotypes of HTLV-1 MA mutantsa
| MA protein | Precursor cleavage index (%) | Particle production index (%) | Infectivity index (%) |
|---|---|---|---|
| Wild type | 100 | 100 | 100 |
| Gly2-Ala | 7 | 1 | 0 |
| Arg3-Leu | 38 | 20 | 0 |
| Arg7-Leu | 50 | 17 | 61 |
| Arg14-Leu | 58 | 16 | 3 |
| Arg17-Leu | 40 | 8 | 6 |
| Arg33-Leu | 63 | 44 | 0 |
| Lys47-Ile | 53 | 40 | 0 |
| Lys48-Ile | 61 | 7 | 2 |
| Lys51-Ile | 72 | 39 | 0 |
| Lys74-Ile | 35 | 28 | 0 |
| Arg79-Leu | 17 | 0 | 0 |
| Arg97-Leu | 73 | 70 | 50 |
| Lys47,48,51-Ile | 0 | 0 | 0 |
a
Data are the means of at least two independent transfections. The precursor cleavage and virus particle production indices were calculated as described in Materials and Methods, and the infectivity index was calculated as described elsewhere (6).