FIG. 2.

Real-time quantitative polymerase chain reaction was used to determine transcript expression for BDNF variants and the TrkB receptor in females (left) and males (right). (A) BDNF variants I, II, and IV. (B) BDNF VI, IX, and the TrkB receptor. A one-way ANOVA with multiple comparisons and Tukey's post hoc test were used to determine differences with a p-value set to 0.05 (*<0.05, **<0.01, ***<0.001, ****<0.0001; ns). The Grubbs test was used to remove single outliers, n=4–6. Error bars represent 95% confidence interval. ANOVA, analysis of variance; CBD, cannabidiol; ns, not significant; T/C, treatment with both THC and CBD; THC, tetrahydrocannabinol; TrkB, tropomyosin receptor kinase B.