Table 2.
Summary of Drug-Loaded Polymeric Scaffolds in Tendon Healing
| Drug or growth factors delivered | Mode of administration | Tendon | Reference |
|---|---|---|---|
| GDF-7 | Quadrol-hexamethylene diisocyanate-methacrylic anhydride polyurethane polymer | Rotator cuff | 66 |
| Ibuprofen | PLGA microspheres within sintered poly (ɛ-caprolactone) electrospun scaffold | Rotator cuff | 47 |
| Ibuprofen | PLGA | Rotator cuff | 67 |
| PDGF-BB | DegraPol® polyester urethane | AT | 68 |
| PDGF-BB | Fibrin/HBDS | Flexor digitorum profundus | 69 |
| PDGF-BB | Fibrin/ HBDS PLGA nanofiber | Flexor digitorum profundus | 44 |
| bFGF | Fibrin/HBDS | Flexor digitorum profundus | 70 |
| rhPDGF-BB | Collagen 1 carrier (BioBlanket) | Rotator cuff | 71 |
| PDGF | Microneedle patch | AT | 72 |
| PDGF-BB | DegraPol tube | AT | 73 |
| bFGF | Dextran glassy nanoparticles electrospun PPLA copolymer fiber | AT | 43 |
| bFGF | PLGA fibrous membranes | Rotator cuff | 74 |
| TGF-β1 | Absorbable alginate scaffold | Rotator cuff | 75 |
| Parathyroid hormone | Alginate scaffold | Rotator cuff | 76 |
| Sprifermin | Sodium alginate hydrogel | Rotator cuff | 77 |
| TGF-β3 or GDF-7 | Cross-linking gelatin (Col-Tgel) | Rotator cuff | 78 |
| Mitomycin-C | Drug-loaded hyaluronan hydrosols encapsulated in PLLA fibrous membranes | AT and FDL | 79 |
GDF-7, growth and differentiation factor 7; HBDS, heparin-based delivery system; PDGF-BB, platelet-derived growth factor-BB; PLGA, poly(lactic-co-glycolic) acid; PPLA, poly-l-lactic acid; TGF-β1, transforming growth factor β1.