Table 2.
Maternal plasma/serum and cord blood concentrations of sertraline and N-desmthylsertraline at deliverya
| Sertraline | N-desmethylsertraline | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Study | N | Dose (mg/d) | Study Location | Maternal Concentration at Delivery (ng/mL) | Cord Concentration at Delivery (ng/mL) | Cord:Maternal Ratio | Maternal Concentration at Delivery (ng/mL) | Cord Concentration at Delivery (ng/mL) | Cord:Maternal Ratio |
| Hostetter, et al. (2000) 28 | 1 | 175 | USA | 45 | 21 | 0.47 | 320 | 194 | 0.61 |
| Rampono, et al. (2004) 31 | 4 | 50 | Australia | 10.5 (9–64) | 10 (5–24) | 0.7 (0.4–1.2) | 37.5 (21–189) | 26.5 (13–93) | 0.63 (0.46–0.81) |
| Sit, et al. (2011) 38 | 9 | Corrected to 50 mg/d (50–200) | USA | 8.1 (3.9–16) | 2.7 (1.5–6.7) | 0.3 (0.19–0.99) | 25.9 (10.8–48.5) | 8.2 (3.4–19) | 0.38 (0.28–0.60) |
| Rampono, et al. (2009) 36,b | 6 | 50 (44–100) | Australia | 15 (11–45) | 6 (4–11) | 0.33 (0.29–0.36) | 45 (35–91) | 16 (12–26) | 0.40 (0.34–0.50) |
| Hendrick, et al. (2003) 29 | 11 | Corrected to 50 mg/d (25–100) | USA | 10 (3–44) | 7 (1–7) | 0.27 (0.1–1) | 51 (5–148) | 15.4 (6–36) | 0.28 (0.1–4) |
| Paulzen, et al. (2017) 43,b | 6 | 75 (43.75–100) | Germany | 15.4 (11.88–20.88) | 5.7 (4.52–7.05) | 0.36 (0.28–0.49) | -- | -- | -- |
| Colombo, et al. (2020) 40,a | 24 | 75 (50–150) | Italy | 12 (6.1–42.6) | 6 (5–35.5) | 0.4 (0.18–1.6) | -- | -- | -- |
| Heinonen, et al. (2021) 45,a | 9 | 75 (50–100) | Sweden | 14.38 (3.64–24.17) | 4.28 (1.22–6.12) | 0.33 (0.14– 1.17) |
33.60 (7.01–31.36) | 9.93 (4.96–17.23) | 0.29 (0.24–1.42) |
a
Median, range
b
Median, Interquartile Range