Table 3.
Maternal plasma/serum and cord blood concentrations of fluoxetine and norfluoxetine
| Fluoxetine | Norfluoxetine | ||||||||
|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||
| Study | N | Dose (mg/d) | Study Location | Maternal Concentration at Delivery (ng/mL) | Cord Concentration at Delivery (ng/mL) | Cord: Maternal Ratio | Maternal Concentration at Delivery (ng/mL) | Cord Concentration at Delivery (ng/mL) | Cord: Maternal Ratio |
| Rampono, et al. (2004) 31 | 4 | 20–40 | Australia | 96 (56–199) | 65(52–149) | 0.67 (0.61–0.75) | 110 (20–252) | 81 (8–252) | 0.72 (0.4–1) |
| Sit, et al. (2011) 38 | 4 | 10–40a | USA | 51.7 (31.3–162) | 26.7 (20–89.1) | 0.55 (0.50–0.64) | 94.7 (12.7–127.5) | 54.9 (8.7–76) | 0.43 (0.48–0.7) |
| Rampono, et al. (2009) 36 | 2 | 30 | Australia | 52; 192 | 37; 141 | 0.71; 0.73 | 126; 52 | 99; 226 | 0.77; 0.79 |
| Hendrick, et al. (2003) 29 | 15 | 10–60a | USA | 45.3 (13–274) | 26 (6–262) | 0.54 (0.32–1.36) | 126 (30–388) | 62 (18–213) | 0.6 (0.12–1.6) |
| Kim, et al. (2006) 48,b | 9 | 10–30 | British Columbia | 38.5 (15.1, 62.1) | 41.3 (16.9, 59.8)) | 0.91 (0.60, 1.02) | 74.6 (41.7, 107.4) | 78.5 (42.3, 114.6) | 1.04 (0.93, 1.15) |
| Heikkinen, et al. (2003) 47 | 11 | 20–40 | Finland | 56.9 ± 37.8 | 34.6 ± 23.2 | 0.61 | 91.5 ± 30.1 | 61.7 ± 23.3 | 0.67 |
| Colombo, et al. (2020) 40,d | 4e | 25 (20–30) | Italy | 147; 216.8 | 152; 108.6 | 1.03; 0.5 | |||
a
Concentrations are dose-corrected to 20 mg dose
b
Reported as mean (95% CI)
c
Reported as mean±SD (range)
d
Reported as median (range)
e
Concentration at delivery only available from 3 subjects, with 1 below LOQ