. Author manuscript; available in PMC: 2024 Jun 1.

Published in final edited form as: J Clin Pharmacol. 2023 Jun;63(Suppl 1):S137–S158. doi: 10.1002/jcph.2282

Table 4.

Maternal plasma/serum and cord blood concentrations of citalopram

				Citalopram			N-desmethylcitalopram
Study	N	Dose (mg/d)	Study Location	Maternal Concentration at Delivery (ng/mL)	Cord Concentration at Delivery (ng/mL)	Cord:Maternal Ratio	Maternal Concentration at Delivery (ng/mL)	Cord Concentration at Delivery (ng/mL)	Cord:Maternal Ratio
Heikkinen, et al. (2002) ^53,a	11	20–40 (dose corrected to 20)	Finland	31.8±10.4	20.2±7.2	0.64
Rampono, et al. (2009) ^36,b	9	20–30	Australia	33(24–51)	27 (20–50)	0.83 (0.77–0.86)	14 (10–18)	12 (9–23)	0.86 (0.82–1.06)
Sit, et al. (2011) ³⁸	1	50	USA	41.4	23	0.56	14.7	10.5	0.71
Hendrick, et al. (2003) ^29,c	4	20–40 (dose corrected to 20)	USA	37.5 (12–64)	22 (5–36)	0.62 (0.17–1.42)	10 (9–20)	10 (5–11)	0.57 (0.5–1.0)
Paulzen, et al. (2017) ^65,c	12	20 (10–40)	Germany	32.75 (7–84.7)	25.15 (5.1–61.7)	0.78 (0.46–1.66)

Mean±SD

Median, IQR

Median, Range