. Author manuscript; available in PMC: 2024 Jun 1.

Published in final edited form as: J Clin Pharmacol. 2023 Jun;63(Suppl 1):S137–S158. doi: 10.1002/jcph.2282

Table 5.

Maternal plasma/serum and cord blood concentrations of paroxetine

				Paroxetine

Study	N	Dose (mg/d)	Study Location	Maternal Concentration at Delivery (ng/mL)	Cord Concentration at Delivery (ng/mL)	Cord:Maternal Ratio
Rampono, et al. (2004) ³¹	2	20 mg/d	Australia	13; 10	7; ND^b; 5	0.54, 0.5

Rampono, et al. (2009) ³⁶	1	30	Australia	13	2	0.15
Hendrick, et al. (2003) ^29,a	11	Corrected to 20 mg/d (10–40 mg)	USA	29 (8–118)	12 (3–48)	0.56 (0.05–0.91)
Oberlander, et al. (2004) ^51,c	3/14	22.5±10.3/20.0±7.7	Canada	4.4±3.3/8.4±8.6	1.5±1.0/3.32±4.6

Median (range)

Study included woman with non-identical twins; paroxetine was not detected in one twin’s cord.

Data stratified by exposed infants with/without transient neonatal symptoms, reported as mean ± SD