Table 6.
Maternal plasma/serum and cord blood concentrations of escitalopram
| Escitalopram | N-desmethylescitalopram | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Study | N | Dose (mg/d) | Study Location | Maternal Concentration at Delivery (ng/mL) | Cord Concentration at Delivery (ng/mL) | Cord:Maternal Ratio | Maternal Concentration at Delivery (ng/mL) | Cord Concentration at Delivery (ng/mL) | Cord:Maternal Ratio |
| Rampono, et al. (2009) 36,a | 8 | 20 (10–28) | Australia | 21 (12–52) | 17 (10–36) | 0.73 (0.71–0.91) | 13 (9–16) | 10 (7–16) | 0.70 (0.66–0.80) |
| Sit, et al. (2011) 38 | 2 | 10 | USA | 5.6; 13.5 | 0; 6.7 | 0; 0.5 | 5.4; 2.6 | 3.6; 2.0 | 0.67; 0.77 |
| Colombo, et al. (2020) 40,b | 7 | 10 (5–10) | Italy | 9.5 (5–36.5) | 7.7 (5–15.9) | 0.491;0.865c | |||
a
Median, IQR
b
Median, range
c
Only two subjects with data above limit of quantification (5ng/mL)