Table 8.
Maternal plasma/serum and cord blood concentrations of venlafaxine
| Venlafaxine | O-desmethylvenlafaxine | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Study | N | Dose (mg/d) | Study Location | Maternal Concentration at Delivery (ng/mL) | Cord Concentration at Delivery (ng/mL) | Cord:Maternal Ratio | Maternal Concentration at Delivery (ng/mL) | Cord Concentration at Delivery (ng/mL) | Cord:Maternal Ratio |
| Rampono, et al. (2009) 36,a | 11 | 225 (150–300) | Australia | 45 (23–64) | 20 (9–53) | 0.72 (0.41–1.11) | 256 (151–294) | 184 (123–348) | 1.08 (0.68–1.17) |
| Sit, et al. (2011) 38 | 2 | 75 | USA | 100; 28.3 | 79.9; 46.4 | 0.8; 1.64 | 56.4; 188 | 44.7; 105 | 0.79; 0.56 |
| Rampono, et al. (2004) 31 | 1 | 150 | Australia | 220 | 232 | 1.1 | 392 | 406 | 1 |
| Hostetter, et al. (2000) 28 | 1b | 150 | USA | 335 | 584; 554 | 1.74; 1.65 | 97 | 304; 325 | 3.13; 3.35 |
| Paulzen, et al. (2020) 54,c | 9 | 75 (37.5–225) | Germany | 18.2 (2–201) | 23.4 (2–157) | 1.00 (0.78–1.77) | 190 (31.9–281) | 204 (19.1–425) | 1.07 (0.60–2.16) |
| Colombo, et al. (2020) 40,c | 7 | 75 (37.5–150) | Italy | 179.9 (76.8–199.8) | 184.8 (78.9–234.7) | 0.40 (0.14–2.41) | |||
a
Median, IQR
b
Twins
c
Median, range