Table 9.
Maternal plasma/serum and cord blood concentrations of nortriptyline
| Nortriptyline | 10-hydroxy nortriptyline | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Study | N | Dose (mg/d) | Study Location | Maternal Concentration at Delivery (ng/mL) | Cord Concentration at Delivery (ng/mL) | Cord:Maternal Ratio | Maternal Concentration at Delivery (ng/mL) | Cord Concentration at Delivery (ng/mL) | Cord:Maternal Ratio |
| Sit, et al. (2011) 38,c | 1 | 0a | USA | 22.6 | 10.6 | 0.47 | 30.8 | 20.1 | 0.65 |
| Loughhead, et al. (2006) 32,b,d | 10 | 75 (30–150) | USA | 27.8 (1.88–102) | 25.5 (2.8–124) | 0.84 (0.25–26.3) | 18.4 (0–132) | 26.1 (0–119) | 0.39 (0–7.3) |
a
75 mg/d at 36 weeks, tapered to 0 mg at delivery
b
Median (Range)
c
E-10-hydroxy nortriptyline
d
Cis-10-hydroxy nortriptyline