Cytotoxicity of 1–11CA against breast cancer (MCF-7 and MDA-MB-231), and non-tumorigenic adherent mouse fibroblast connective tissue (L929) cells after 72 h of exposure. See Table S6 in the ESI† for the full statistical analysis.
| Compound | IC50 (μM) (average ± standard deviation) 72 h | SIa | ||
|---|---|---|---|---|
| MCF-7 | MDA-MB-231 | L929 | ||
| 1 | 48 ± 10 | 41 ± 3 | 58 ± 4 | 1.3 |
| 2 | 51 ± 6 | 63 ± 3 | 64 ± 4 | 1.1 |
| 3 | 51 ± 4 | 60 ± 3 | 84 ± 5 | 1.5 |
| 4 | 68 ± 7 | 83 ± 4 | 79 ± 4 | 1.0 |
| 5 | 57 ± 5 | 71 ± 4 | 84 ± 4 | 1.3 |
| 6 | 74 ± 7 | 63 ± 5 | 82 ± 3 | 1.2 |
| 7 | 62 ± 4 | 83 ± 5 | 104 ± 4 | 1.4 |
| 8 | 41 ± 5 | 50 ± 2 | 50 ± 3 | 1.1 |
| 9 | 52 ± 7 | 44 ± 3 | 70 ± 4 | 1.5 |
| 10 | 3.1 ± 0.2 | 2.8 ± 0.2 | 31 ± 3 | 10.5 |
| 11Cl | 0.061 ± 0.003 | 0.086 ± 0.006 | 0.87 ± 0.05 | 11.8 |
| 11NO3 | 0.078 ± 0.005 | 0.109 ± 0.009 | 1.04 ± 0.05 | 11.1 |
| 11BF4 | 0.14 ± 0.01 | 0.19 ± 0.01 | 1.13 ± 0.05 | 6.8 |
| 11OTf | 0.60 ± 0.07 | 1.4 ± 0.1 | 1.8 ± 0.2 | 1.8 |
| 11PF6 | 0.15 ± 0.01 | 0.16 ± 0.01 | 0.17 ± 0.01 | 1.1 |
| 11SbF6 | 0.08 ± 0.01 | 0.131 ± 0.009 | 1.35 ± 0.09 | 12.8 |
| 11BPh4 | 0.52 ± 0.06 | 1.7 ± 0.3 | 3.9 ± 0.3 | 3.5 |
a
The selectivity index (SI) was calculated as IC50 non-cancerous L929 cells divided by the average of the IC50 of the breast cancer cell lines.