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A representative snapshot showing the orientation of the NPT2A internal 494TRL494 PDZ motif. Thr494 and Leu496 are solvent-exposed, whereas Arg495 is buried within the pocket created by TM5a, TM6a, and TM6b. A predicted salt bridge between Arg495 (TM6b) and Glu438 (TM5a) is presented as a dotted black line. The TM helices in the MD model were assigned as published elsewhere [28].
