Table 3.

Weight loss driven improvement of methylation age.

Study	Participants	Methods	Results	References
weight loss intervention/18-month Aim: evaluated the role of multiple factors on the deviation of mAge from chronological age	120 CENTRAL participants with abdominal obesity or dyslipidemia (BMI = 30.2 ± 3.3, 10 female/110 male, Age = 48.6 ±9.3) Tissue: blood	Illumina HumanMethylation 850K BeadChips	with abdominal obesity or dyslipidemia, mAge was higher than the chronological age; weight loss lifestyle intervention attenuated the mAging of the men by 7.1 months	Yaskolka Meir et al. 2021 (66)
Weight loss intervention/12 weeks Aim: examined the association between changes in physical function and DNA-methylation-based biological age at baseline and 12 weeks.	16 older adults with obesity (BMI= 36.2 ± 7.0, Age = 73.50 ± 5.72, 14 female/2 male) Tissue: blood	Illumina HumanMethylation 850K BeadChips	Participants mean weight loss was 4.6 kg and DNA methylation age decreased by 0.8; decreased methylation age was associated with significantly increased gait speed	Peterson et al. 2021 (65)

This table summarizes the studies, which deal with the improvement of the methylation age through weight loss. mAge, methylation age.