Table 3.
Hospitalization or Mortality in HFrEF and HFpEF
| Comorbidity Group | HFrEF |
HFpEF |
||||||
|---|---|---|---|---|---|---|---|---|
| No. at Risk | No. of Events | Unadjusted HR (95% CI) | Adjusted HR (95% CI)a | No. at Risk | No. of Events | Unadjusted HR (95% CI) | Adjusted HR (95% CI)a | |
| All-cause deaths or heart failure hospitalization at 1 y | ||||||||
| No DM, no CKD | 1,163 | 155 (13.3) | 1.00 (Ref) | 1.00 (Ref) | 367 | 20 (5.5) | 1.00 (Ref) | 1.00 (Ref) |
| DM only | 771 | 163 (21.1) | 1.66 (1.33-2.07) | 1.43 (1.14-1.80) | 261 | 19 (7.3) | 1.35 (0.72-2.53) | 1.01 (0.52-1.95) |
| CKD only | 735 | 170 (23.1) | 1.84 (1.48-2.29) | 1.43 (1.14-1.80) | 248 | 45 (18.2) | 3.62 (2.14-6.12) | 2.54 (1.46-4.41) |
| DM+CKD | 944 | 338 (35.8) | 3.08 (2.55-3.73) | 2.07 (1.68-2.55) | 378 | 87 (23.0) | 4.66 (2.87-7.58) | 2.37 (1.40-4.02) |
| All-cause deaths or all-cause hospitalization at 1 y | ||||||||
| No DM, no CKD | 1163 | 302 (26.0) | 1.00 (Ref) | 1.00 (Ref) | 367 | 56 (15.3) | 1.00 (Ref) | 1.00 (Ref) |
| DM only | 771 | 255 (33.1) | 1.33 (1.13-1.57) | 1.19 (1.00-1.41) | 261 | 55 (21.1) | 1.42 (0.98-2.07) | 1.12 (0.76-1.66) |
| CKD only | 735 | 261 (35.6) | 1.44 (1.22-1.70) | 1.16 (0.98-1.39) | 248 | 79 (31.9) | 2.34 (1.66-3.29) | 1.71 (1.19-2.45) |
| DM+CKD | 944 | 456 (48.4) | 2.18 (1.88-2.52) | 1.58 (1.34-1.85) | 378 | 154 (40.7) | 3.20 (2.36-4.35) | 1.90 (1.36-2.66) |
Values are n (%), unless otherwise indicated.
a
Adjusted for age, sex, ethnicity, enrollment type, regional income, systolic BP, heart rate, ejection fraction, coronary artery disease, chronic obstructive pulmonary disease, atrial fibrillation, peripheral arterial vascular disease, use of ACE inhibitors, ARBs, beta-blockers, and diuretics.