Table 2.

Biomarkers by Type of Anticoagulant at Enrollment

	No-OAC (n = 157)	Warfarin (n = 728)	DOAC (n = 2,289)	DOAC (Excluding Off-Label Doses) (n = 1,916)
D-dimer (μg/mL)
<1.0	106 (67.5)	625 (83.7)	2,057 (89.8)	1,721 (89.8)
≥1.0	51 (32.5)	103 (13.8)	232 (10.1)	195 (10.2
TAT (ng/mL)
≤3	133 (84.7)	682 (91.3)	2,142 (93.5)	1,795 (93.7)
>3	24 (15.3)	46 (6.2)	147 (6.4)	121 (6.3)
F1+2 (pmol/L)
<69	1 (0.6)	165 (22.1)	8 (0.3)	7 (0.4)
≥69 to <229	37 (23.6)	480 (64.3)	1,585 (69.2)	1,334 (69.6)
≥229	119 (75.8)	83 (11.1)	696 (30.4)	575 (30.0)
SFMC
Negative	122 (77.7)	613 (82.1)	1,823 (79.6)	1,521 (79.4)
Positive	35 (22.3)	112 (15.0)	463 (20.2)	393 (20.5)

Values are n (%).

F1+2 = prothrombin fragment 1+2; SFMC = soluble fibrin monomer complex; TAT = thrombin–antithrombin complex; other abbreviations as in Table 1.