Table 1.
Baseline Characteristics of ABC-Adherent and Nonadherent Patients
| ABC Nonadherent (n = 2,464) | ABC Adherent (n = 1,549) | P Value | |
|---|---|---|---|
| Age (y) | 70.2 ± 11.5 | 65.8 ± 11.9 | <0.001 |
| Female | 868 (35.2) | 511 (33.0) | 0.146 |
| AF pattern | |||
| First diagnosed | 193 (7.9) | 97 (6.3) | <0.001 |
| Paroxysmal | 1,003 (40.9) | 675 (43.7) | |
| Persistent | 540 (22.0) | 421 (27.2) | |
| Longstanding persistent | 246 (10.0) | 142 (9.2) | |
| Permanent | 473 (19.3) | 211 (13.6) | |
| Concomitant disease | |||
| Hypertension | 1,660 (67.8) | 792 (51.3) | <0.001 |
| CAD | 670 (27.6) | 112 (7.2) | <0.001 |
| HF | 692 (28.4) | 159 (10.3) | <0.001 |
| Diabetes | 740 (30.4) | 246 (15.9) | <0.001 |
| Lipid disorder | 1,004 (41.4) | 519 (33.9) | <0.001 |
| Smoker | 204 (8.3) | 136 (8.8) | 0.579 |
| Previous stroke/TIA | 297 (12.2) | 90 (5.8) | <0.001 |
| Previous bleedings | 233 (9.5) | 67 (4.3) | <0.001 |
| ICH | 52 (2.1) | 16 (1.0) | 0.010 |
| Major extracranial bleeding | 99 (4.0) | 26 (1.7) | <0.001 |
| PAD | 43 (1.8) | 5 (0.3) | <0.001 |
| CKD | 219 (8.9) | 90 (5.8) | <0.001 |
| COPD | 79 (3.2) | 30 (1.9) | 0.016 |
| Cancer | 68 (2.8) | 25 (1.6) | 0.019 |
| Dementia | 60 (2.4) | 9 (0.6) | <0.001 |
| Anemia | 225 (9.2) | 65 (4.2) | <0.001 |
| Symptomatic status | |||
| EHRA I | 1523 (61.8) | 1049 (67.7) | <0.001 |
| EHRA II | 684 (27.8) | 500 (32.3) | |
| EHRA III | 228 (9.3) | 0 (0.0) | |
| EHRA IV | 29 (1.2) | 0 (0.0) | |
| Thrombotic and hemorrhagic risk | |||
| CHA2DS2-VASC score | 3.1 ± 1.7 | 2.1 ± 1.5 | <0.001 |
| HAS-BLED | 1.5 ± 1.1 | 1.1 ± 0.9 | <0.001 |
Values are mean ± SD or n (%).
AF = atrial fibrillation; CAD = coronary artery disease; CKD = chronic kidney disease; COPD = chronic obstructive pulmonary disease; EHRA = European Heart Rhythm Association; HF = heart failure; ICH = intracranial hemorrhage; PAD = peripheral artery disease; TIA = transient ischemic attack.