Table 1.
Characteristics of a subset of participants in the NCI’s Combined DES Cohort Study and Sister Study Cohort by prenatal exposure to diethylstilbestrol (DES).
| NCI’s Combined DES Cohort Study | Sister Study Cohort | |||
|---|---|---|---|---|
|
| ||||
| Characteristics | DES Exposed (N=40) |
DES Unexposed (N=20) |
DES Exposed (N=99) |
DES Unexposed (N=100) |
| Age (years), mean (range) | 60.3 (51.0-67.0) | 61.2 (55.0-67.0) | 50.6 (40.0-58.0) | 50.7 (40.0-59.0) |
| Body mass index (BMI) (kg/m2), mean (range) | 30.0 (20.9-55.4) | 28.3 (18.7-47.1) | 25.7 (19.0-47.8) | 27.7 (17.5-47.5) |
| Age at menarche (years), mean (range) | 12.7 (9.00-15.0) | 12.5 (11.0-16.0) | 12.9 (9.0-16.0) | 12.6 (9.0-17.0) |
| Age at menopause (years), mean (range) | 50.9 (40.0-57.0) | 51.5 (47.0-57.0) | 47.1 (31-55) | 47.1 (32-56) |
| Parous, n (%) | ||||
| No | 15 (37.5) | 10 (50.0) | 39 (39.4) | 21 (21.0) |
| Yes | 25 (62.5) | 10 (50.0) | 60 (60.6) | 79 (79.0) |
| Alcohol*, n (%) | ||||
| No | 26 (65.0) | 17 (85.0) | 64 (64.6) | 58 (58.0) |
| Yes | 14 (35.0) | 3 (15.0) | 35 (35.4) | 42 (42.0) |
| Ever smoked**, n (%) | ||||
| No | 21 (52.5) | 11 (55.0) | 55 (55.6) | 62 (62.0) |
| Yes | 19 (47.5) | 9 (45.0) | 44 (44.4) | 38 (38.0) |
| Gestational age at DES exposure (weeks), mean (range) | 10.8 (3.00-30.0) | - | Not collected | Not collected |
| DES dose, mean (range) | 8,347.3 (480-16,475) | - | Not collected | Not collected |
| Vaginal Epithelial Changes (VEC), n (%) | ||||
| No | 4 (10.0) | 20 (100%) | Not collected | Not collected |
| Yes | 36 (90.0) | - | Not collected | Not collected |
*
For the NCI’s Combined DES Cohort study, alcohol consumption refers to consumption within 24 hours before blood collection. For the Sister Study Cohort, it refers to general alcohol consumption.
**
For the NCI’s Combined DES Cohort study, smoking data was collected in the 2006 cohort follow-up questionnaire. For the Sister Study Cohort, information was collected at study entry.