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| system (solvent) method | d1 | d2 | d3 |
|---|---|---|---|
| kd1 (s–1) | kd2 (s–1) | kd3 (s–1) | |
| t1/2 (min) | t1/2 (min) | t1/2 (min) | |
| 8a (DMSO-d6) extrapolated | 3.28 ± 0.25 × 10–4 | 1.66 ± 0.23 × 10–3 | 6.83 ± 0.68 × 10–5 |
| 35.3 ± 2.5 | 7.0 ± 1.0 | 170 ± 17 | |
| 8a (DMSO-d6) isolated | 3.33 ± 0.25 × 10–4 | 2.33 ± 0.15 × 10–3 | 8.33 ± 1.02 × 10–5 |
| 34.7 ± 2.6 | 5.0 ± 0.3 | 139 ± 17 |
