Table 3.
Composition of the N-glycan structures in Varlilumab co-expressed with β1,4-GALT in N. benthamiana.
| Abbreviation | Structure | Soil-based (%) | Hydroponic-based (%) |
|---|---|---|---|
| M2 | Man2 | 1.7 | – |
| M3 | Man3 | 8.2 | 9.6 |
| M4 | Man4 | 5.4 | – |
| M5 | Man5 | 5.3 | – |
| M8 | Man8 | 5.1 | – |
| M9 | Man9 | 5.7 | – |
| M3X | Man3Xyl | 5.2 | 6.9 |
| GNM3 | GlcNAcMan3 | 2.3 | 7.7 |
| GNM3X | GlcNAcMan3Xyl | – | 9.4 |
| GNM5 | GlcNAcMan5 | 14.8 | 11.1 |
| GNM5X | GlcNAcMan5Xyl | 3.7 | – |
| Gal(β1,4)GNM3 | GalGlcNAcMan3 | 12.5 | 24.8 |
| Gal(β1,4)GNM3X | GalGlcNAcMan3Xyl | 8.8 | 20.5 |
| Gal(β1,4)GNM5 | GalGlcNAcMan5 | 21.2 | 10.0 |
| Total | 100 | 100 | |
|
Terminal β1,4-Gal residue
β1,2-Xylosylated Oligomannosidic structure |
42.5 17.7 21.5 |
55.3 36.8 - |
|