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. 2023 Jun 5;7(8):e10776. doi: 10.1002/jbm4.10776

Fig. 2.

Fig. 2

MicroRNA (miR) expression by RT‐qPCR in rheumatoid arthritis (RA) osteoclasts. miR RNA extraction was performed at the end of osteoclast cultures, followed by real‐time RT‐qPCR of the 25 selected miRs. miR expression was normalized to snU6 in peripheral blood mononuclear cell (PBMC)‐derived osteoclasts in patients with established erosive (E) or nonerosive (NE) RA and in age‐ and sex‐matched controls (Cont), n = 21/group. (A) Expression of 25 miRs in osteoclast cultures. The results are presented as a heat map reflecting the log2 relative expression in the 3 groups: controls, nonerosive RA, and erosive RA. The p values are indicated: *p < 0.05, **p < 0.01, ***p < 0.001 (E versus NE), ## p < 0.01, ### p < 0.001 (Cont versus E). (B) Five top miRs differentially expressed in osteoclast cultures. Boxplot: mean, SD; the FDR adjusted p values are indicated: *p adj <0.05, **p adj <0.01 (E versus NE), # p adj <0.05, ## p < 0.01 (Cont versus E).