Central Illustration.

Cardiovascular Risk Factor Disparities Among Survivors Compared With the General Population

The burden of diabetes, hypertension, hyperlipidemia, obesity, and multiple cardiovascular risk factors (CVRFs) contribute to the incidence of cardiovascular disease (CVD) across the life span for both survivors and the general population. For survivors, anthracyclines and chest radiation are directly cardiotoxic, whereas CVRFs are known to potentiate risk for CVD beyond the expected additive risk, thus emphasizing the increased importance to mitigate CVRFs among survivors and motivating further actions to provide equitable survivorship-focused care for all survivors. This analysis observed similar disparities by race/ethnicity compared with the general population, with non-Hispanic Black and Hispanic survivors reporting a higher cumulative incidence of diabetes, obesity, and multiple CVRFs. CCSS = Childhood Cancer Survivor Study; CV = cardiovascular; CVD = cardiovascular disease; NHANES = National Health and Nutrition Examination Survey.