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. Author manuscript; available in PMC: 2024 Aug 9.
Published in final edited form as: J Am Chem Soc. 2023 Jul 26;145(31):17461–17467. doi: 10.1021/jacs.3c06225

Table 1.

Ruthenium-catalyzed [4+2] cycloaddition of benzocyclobutenones 7a-h with α-ketols 12a-g.a

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a

Yields of material isolated by silica gel chromatography. Enantioselectivities were determined by chiral stationary-phase HPLC analysis. Diastereoselectivities were determined by 1H NMR analysis of crude reaction mixtures.

b

Diol (200 mol%).

c

Ru3(CO)12 (10 mol%), (R)-DM-SEGPHOS (30 mol%), 140 °C, 48 hr.

d

Ru3(CO)12 (3.3 mol%), (R)-DM-SEGPHOS (10 mol%), 140 °C. ND = Not determined. See Supporting Information for further details.