Figure 3.

Biological outcomes of increased Myc protein levels. Myc levels are tightly controlled within the cell. It may increase in narrow windows of expression upon mitogenic stimuli ruling the physiological homeostasis of highly regenerating permissive tissues and upon tissue damage. In highly terminally differentiated tissues, refractory to proliferation signals, Myc levels increased upon both acute and chronic tissue damage, with different outcomes. Indeed, either repair or tissue degeneration may occur. As well established, sustained and uncontrolled Myc levels promote its oncogenic properties.