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. Author manuscript; available in PMC: 2023 Aug 22.
Published in final edited form as: Annu Rev Biochem. 2023 Apr 17;92:145–173. doi: 10.1146/annurev-biochem-052521-035330

Figure 4. Targets of m6A eraser proteins.

Figure 4.

a) In the nucleus, FTO and ALKBH5 demethylate m6A sites in mRNAs. FTO can also remove m6A and m6Am in lncRNAs and snRNAs. b) In the cytoplasm, FTO can remove m6A and m6Am from mRNAs and m1A from tRNA. In the nervous system, FTO expression is regulated by activity and can promote m6A demethylation of specific transcripts in axons. ALKBH5 expression is increased in hypoxic conditions and in cancer cells, resulting in decreased m6A levels of specific mRNAs and enhanced cell proliferation and stem cell self-renewal.