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. 2023 Jul 24;8(14):e165358. doi: 10.1172/jci.insight.165358

Figure 6. HS-276 inhibited bleomycin-induced lung fibrosis.

Figure 6

C57BL/6 mice were randomized to 4 treatment groups and euthanized on day 22, and lungs were harvested. (A) H & E stain. Representative images. Scale bar: 200 μm. (B) Hydroxyproline assays, left lungs (n = 3–4). Results are mean ± SEM. One-way ANOVA followed by Tukey’s multiple-comparison test. (C–E) Lung sections were immunolabeled with antibodies to phospho-TAK1 (scale bar: 10 μm), CD45 (scale bar: 50 μm), F4/80 (scale bar: 50 μm), and DAPI (blue). Representative images (left panel); quantification of immunopositive cells (right panel, means from 3 randomly selected regions from 4 mice/group). One-way ANOVA followed by Tukey’s multiple-comparison test.