Table 1. Information about the patients included in the 6-month evaluation.
| Case | Breed | Sex | BW (kg) | Age at onset (year) | Seizure type classification | First treatment | Second treatment after protocol change | Blood concentration | Seizure frequency per month (before referral) | Seizure frequency per month (after 6 months) | Reduction of seizure frequency | CS/SE (before referral) | CS/SE (after 6 months) | Response evaluation | Adverse effects |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| #1 | ASH | SF | 3.4 | 1.9 | Focal epileptic seizures evolving into generalized epileptic seizures | PB 1.5 kg/kg BID | PB 2.3 mg/kg BID | PB 19 μg/ml (2nd) | 10.0 | 0 | 100% | none | none | primary goal | none |
| #2 | Chartreux | CM | 4.8 | 8.4 | Generalized | PB 1.6 mg/kg BID | PB 1.5 mg/kg BID | N/A | 1.7 | 0 | 100% | none | none | primary goal | none |
| #3 | DSH | SF | 3.1 | 3.9 | Focal | PB 1.7 mg//kg BID | PB 2 mg/kg BID | N/A | 1.2 | 0 | 100% | none | none | primary goal | none |
| #4 | DSH | CM | 3.9 | 0.3 | Generalized | PB 2 mg/kg BID | PB 2 mg/kg BID | N/A | 6.7 | 0 | 100% | CS | none | primary goal | none |
| #5 | DSH | CM | 3.2 | 2.4 | Generalized | PB 2.4 mg/kg BID | PB 2.4 mg/kg BID | PB 24.3 μg/ml (1st and 2nd) | 0.5 | 0 | 100% | CS | none | primary goal | none |
| #6 | DSH | CM | 3.5 | 3.2 | Generalized | PB 2.8 mg/kg BID | PB 2 mg/kg BID | N/A | 30.0 | 0 | 100% | CS | none | primary goal | none |
| #7 | DSH | F | 3.0 | 12.7 | Generalized | PB 3 mg/kg BID | PB 3 mg/kg BID | N/A | 30.0 | 0.5 | 98% | CS | none | secondary goal | none |
| #8 | Munchkin | SF | 3.2 | 3.1 | Generalized | PB 6 mg/kg SID | PB 6 mg/kg SID | N/A | 6.7 | 0 | 100% | CS | none | primary goal | Depressed proprioception of hind limbs |
| #9 | Scottish fold | SF | 4.1 | 3.8 | Generalized | ZNS 6 mg/kg BID | PB 2 mg/kg BID | N/A | 3.0 | 0 | 100% | none | none | primary goal | Persistent diarrhea (ZNS) |
| #10 | DSH | SF | 3.2 | 0.4 | Generalized | PB 5 mg/kg BID | PB 7.5 mg/kg BID and DZP 0.5 mg/kg BID | N/A | 3.8 | 2 | 48% | CS | none | secondary goal | Dullness (PB ~ PB + DZP) |
| #11 | DSH | CM | 6.1 | 4.2 | Generalized | PB 2.6 mg/kg BID and DZP 0.08 mg/kg SID | PB 2.6 mg/kg BID and DZP 0.08 mg/kg SID | PB 29.8 μg/ml (1st and 2nd) | N/A | 0 | 100% | none | none | primary goal | Elevation of liver enzyme (PB + DZP) |
| #12 | Russian blue | F | 2.3 | 1.2 | Focal | PB 3 mg/kg BID | PB 2 mg/kg BID ZNS 7.4 mg/kg BID | N/A | 8.6 | 5 | 42% | none | none | no responder | Elevation of liver enzyme (PB + ZNS) |
| #13 | DSH | CM | 4.4 | 0.6 | Generalized | PB 1.7 mg/kg BID and ZNS 9 mg/kg BID | PB 6 mg/kg BID and ZNS 1.5 mg/kg BID | N/A | 1.9 | 0 | 100% | SE | none | primary goal | none |
| #14 | Scottish fold | F | 3.2 | 1.7 | Generalized | ZNS 2.2 mg/kg BID | PB 1.2 mg/kg BID and ZNS 7.3 mg/kg BID | PB 24 μg/ml and ZNS 36.9 μg/ml (2nd) | 6.4 | 0 | 100% | none | none | primary goal | none |
| #15 | Chinchilla | SF | 1.8 | 13.5 | Generalized | ZNS 5.4 mg/kg BID | ZNS 7.2 mg/kg BID | ZNS 28.9 μg/ml (2nd) | 5.0 | 0 | 100% | none | none | primary goal | none |
| #16 | Siberian | M | 5.3 | 0.8 | Generalized | ZNS 10 mg/kg BID | ZNS 6.5 mg/kg BID | ZNS 86.4 μg/dl (1st) | 2.0 | 2 | 0% | CS | none | secondary goal | Increase in sleeping hours (ZNS) |
| #17 | ASH | SF | 5.1 | 12.8 | Generalized | ZNS 12 mg/kg BID | ZNS 10 mg/kg BID | ZNS 29.2 μg/ml (2nd) | 18.8 | 0 | 100% | SE | none | primary goal | none |
| #18 | DSH | CM | 2.4 | 0.4 | Generalized | ZNS 5.3 mg/kg BID and DZP 0.53 mg/kg BID | ZNS 7.8 mg/kg BID DZP 0.78 mg/kg BID | N/A | 6.6 | 0 | 100% | CS | none | primary goal | none |
| #19 | Munchkin | SF | 4.5 | 3.2 | Focal | ZNS 5.5 mg/kg BID and LEV 20 mg/kg TID | ZNS 5.5 mg/kg BID and DZP 0.25 mg/kg BID | ZNS 39.3 μg/ml (2nd) | 30.0 | 0 | 100% | none | none | primary goal | Vomiting (ZNS + LEV); ataxia (PB + ZNS) |
| #20 | DSH | CM | 4.8 | 0.7 | Generalized | ZNS 8 mg/kg SID | LEV 25 mg/kg TID, ZNS 4 mg/kg BID and DZP 0.23 mg/kg BID | N/A | 10.0 | 0 | 100% | CS | none | primary goal | Vomiting (ZNS) |
(BW): body weight; (ASH): American short hair; (DSH): Domestic short hair; (SF): Spayed female; (CM): casted male; (F): intact female; (PB): phenobarbital; (ZNS): zonisamide; (DZP): diazepam; (LEV): levetiracetam; (CS): cluster seizures; (SE): status epilepticus.