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. 2023 Aug 22;18(8):e0290046. doi: 10.1371/journal.pone.0290046

Fig 5. T cell mediated immune response: IFNγ and IL4.

Fig 5

(A, B) Strong IFNγ mediated T cell immune-response at day 14 (A) and day 40 (B). STX-S immunization resulted in increased IFNγ response as early as 2 weeks after the first dose after in vitro stimulation with 10ug/mL spike protein. (C-D) IL4 mediated T cell immune-response at day 14 (C) and 40 (D). STX-S immunization resulted in increased baseline IL4 response compared to PBS control likely due to the time point of data collection, with an additional increase after in vitro spike stimulation. N = 10/experimental group. Data are shown as mean±SEM. *p<0.05, **p<0.01, ***p<0.005, ****p<0.001, 1-way ANOVA; ns = not significant.